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Posted by / 13-Sep-2020 11:02


It exhibits only peripheral activity since it does not readily cross the blood-brain barrier; hence, it does not normally cause drowsiness because it does not readily enter the central nervous system.

Desloratadine does not have a strong effect on a number of tested enzymes in the cytochrome P450 system.

The sympathetic system takes over during periods of extreme danger and stress, focusing all the body’s resources on immediate survival. They also increase blood flow to the muscles and brain, increase strength, increase endurance, reduce inflammation, increase mental alertness, and focus attention on the danger.

This is exactly what you want if you’re in a life-threatening situation.

It was found to weakly inhibit CYP2B6, CYP2D6, and CYP3A4/CYP3A5, and not to inhibit CYP1A2, CYP2C8, CYP2C9, or CYP2C19.

Desloratadine was found to be a potent and relatively selective inhibitor of UGT2B10, a weak to moderate inhibitor of UGT2B17, UGT1A10, and UGT2B4, and not to inhibit UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B15, UGT1A7, and UGT1A8.

Treating PTSD quickly can avoid these wounds, since our brain is designed for short bursts from our sympathetic nervous system.

Desloratadine is metabolized to 3-hydroxydesloratadine in a three-step sequence in normal metabolizers.

First, n-glucuronidation of desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine N-glucuronide by CYP2C8; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide.

But prolonged exposure to those same stress chemicals is harmful to your physical and mental health.

WHAT HAPPENS IN THE BRAIN: The colored areas in this brain highlight the parts involved in emotion.


However, the safety profile for these subjects is not worse than for extensive (normal) metabolizers.